HCID 86599925, compound → HCID 17989120, compound

HRID 1443226Notes

Reaction equation

HRID 1443226 reaction equation
[CH2:1]([O:3][C:4](=[O:19])/[CH:5]=[CH:6]/[C:7]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([O:17][CH3:18])[CH:11]=1)([CH3:9])[CH3:8])[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:19])[CH2:5][CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([O:17][CH3:18])[CH:11]=1)([CH3:8])[CH3:9])[CH3:2]

Participants

4

Reactant 1

HCID 86599925HCID 86599925, compound

Product 1

HCID 17989120HCID 17989120, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

24.1 g (85.23 mmol) of ethyl-E-4-(4-chloro-3-methoxyphenyl)-4-methylpent-2-enoate is mixed in 228 ml of ethyl acetate with 2.41 g of palladium on carbon (10%) and stirred overnight at room temperature under hydrogen atmosphere. The catalyst is removed by filtration through a glass fiber filter, and the residue that remians after the concentration by evaporation (24.1 g =99.1%) is incorporated in crude form into the next stage.

Workup

  1. customThe catalyst is removed by filtration through a glass fiber
  2. filtrationfilter
  3. concentrationthe residue that remians after the concentration
  4. customby evaporation (24.1 g =99.1%)

Sources & evidence

ORD record
ord-6825cc102a8447e7925fbfceaf913ba2
Source dataset
uspto-grants-2010_02
Patent number
US07659297B2

Reaction notes

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