HRID1443443

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=C[C@H]1C[C@@]1(NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C)C(=O)OCC

HCID57563804

未命名化合物

PRODUCTS

生成物

结构：C=C[C@H]1C[C@@]1(NC(=O)[C@@H]1C[C@@H](O)CN1)C(=O)OCC

HCID68409004

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

Compound 59 was kept in 30% trifluoroacetic acid in dichloromethane and 1% MeOH for 2 hrs before it was concentrated to dryness. The residue was re-dissolved in dichloromethane and during stirring 1N NaOH was added to pH 10-11. The organic layer was separated and concentrated which gave 1.6 g of the title compound. HPLC purity ca. 90% (M+H)+ 269.1.

WORKUP

后处理

concentration1% MeOH for 2 hrs before it was concentrated to dryness
dissolutionThe residue was re-dissolved in dichloromethane
additionwas added to pH 10-11
customThe organic layer was separated
concentrationconcentrated which