反应详情

The above amide (79) (3.0 g, 9 mmol) was refluxed for three hours in a mixture of sodium carbonate (2.4 g, 22.5 mmol) in EtOH (70 ml) and water (70 ml). The mixture was acidified with 5% citric acid and extracted three times with a mixture of ethyl acetate-THF (4:1). The organic phase was dried with sodium sulfate and evaporated under reduced pressure. The product was purified by column chromatography on silica gel eluted with DCM containing 3% MeOH which gave the title compound (1.95 g).

1. extractionextracted three times
2. additionwith a mixture of ethyl acetate-THF (4:1)
3. dry with materialThe organic phase was dried with sodium sulfate
4. customevaporated under reduced pressure
5. customThe product was purified by column chromatography on silica gel
6. washeluted with DCM containing 3% MeOH which