Citric Acid → HCID 178487744, compound

Participants

Reaction Steps

The above amide (79) (3.0 g, 9 mmol) was refluxed for three hours in a mixture of sodium carbonate (2.4 g, 22.5 mmol) in EtOH (70 ml) and water (70 ml). The mixture was acidified with 5% citric acid and extracted three times with a mixture of ethyl acetate-THF (4:1). The organic phase was dried with sodium sulfate and evaporated under reduced pressure. The product was purified by column chromatography on silica gel eluted with DCM containing 3% MeOH which gave the title compound (1.95 g).

Provenance & Evidence