HRID1443455

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@H](O)C[C@H]1C(=O)OC(C)(C)C)C(=O)OCC

HCID59165438

未命名化合物

HCID178487728

未命名化合物

PRODUCTS

生成物

结构：C=CC1CC1(NC(=O)C1CC(Oc2nc(-c3ccccc3)nc3c(C)c(OC)ccc23)CC1C(=O)OC(C)(C)C)C(=O)OCC

HCID68409413

未命名化合物

收率 75.8%

PROCEDURE

实验过程

Quinazolinol derivative (83) (480 mg, 1.8 mmol) was coupled to compound 15 (0.55 mg, 1.5 mmol) as described in example 16, which gave the title compound (700 mg, 75%)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-612d3c31a1464540b23df7105cb57bd8
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07659245B2
来源说明: uspto-grants-2010_02

反应 SMILES

[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([C:7]([OH:20])=[N:8][C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:10]2)=[CH:5][CH:4]=1.[C:21]([O:25][C:26]([C@@H:28]1[CH2:32][C@@H:31](O)[CH2:30][C@H:29]1[C:34](=[O:46])[NH:35][C@:36]1([C:41]([O:43][CH2:44][CH3:45])=[O:42])[CH2:38][C@H:37]1[CH:39]=[CH2:40])=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:25][C:26]([CH:28]1[CH2:32][CH:31]([O:20][C:7]2[C:6]3[C:11](=[C:12]([CH3:13])[C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[N:10]=[C:9]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:8]=2)[CH2:30][CH:29]1[C:34](=[O:46])[NH:35][C:36]1([C:41]([O:43][CH2:44][CH3:45])=[O:42])[CH2:38][CH:37]1[CH:39]=[CH2:40])=[O:27])([CH3:24])([CH3:22])[CH3:23]