(1R,2R,4S)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl) 4-hydroxy-cyclopentanecarboxylic acid tert-butyl ester → 2-(1-Ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	(1R,2R,4S)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl) 4-hydroxy-cyclopentanecarboxylic acid tert-butyl ester	HCID 59165438	—
Reactant	HCID 178487728	HCID 178487728	—
Product	2-(1-Ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester	HCID 68409413	75.8%

Reaction Steps

Quinazolinol derivative (83) (480 mg, 1.8 mmol) was coupled to compound 15 (0.55 mg, 1.5 mmol) as described in example 16, which gave the title compound (700 mg, 75%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07659245B2
Source dataset	uspto-grants-2010_02
ORD ID	ord-612d3c31a1464540b23df7105cb57bd8
Source note	uspto-grants-2010_02