HCID 76593241, compound → HCID 75290666, compound

HRID 1443463Notes

Reaction equation

HRID 1443463 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([O:18][CH:19]3[CH2:37][CH:36]4[N:21]([C:22](=[O:57])[N:23](CC5C=CC(OC)=CC=5)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH:29]=[CH:30][CH:31]5[C:33]([C:39]([NH:41][S:42]([CH:45]6[CH2:47][CH2:46]6)(=[O:44])=[O:43])=[O:40])([NH:34][C:35]4=[O:38])[CH2:32]5)[CH2:20]3)[C:15]3[C:10](=[C:11]([CH3:60])[C:12]([O:58][CH3:59])=[CH:13][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1>ClCCl.FC(F)(F)C(O)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:17]=[C:16]([O:18][CH:19]3[CH2:37][CH:36]4[N:21]([C:22](=[O:57])[NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH:29]=[CH:30][CH:31]5[C:33]([C:39]([NH:41][S:42]([CH:45]6[CH2:47][CH2:46]6)(=[O:44])=[O:43])=[O:40])([NH:34][C:35]4=[O:38])[CH2:32]5)[CH2:20]3)[C:15]3[C:10](=[C:11]([CH3:60])[C:12]([O:58][CH3:59])=[CH:13][CH:14]=3)[N:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 76593241HCID 76593241, compound

Product 1

HCID 75290666HCID 75290666, compoundYield 38.5%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Compound 103 (75 mg, 0.09 mmol) was stirred for 2 h in a mixture of dichloro-methane-trifluoroacetic acid; 2:1. Evaporation and purification by HPLC gave pure title compound (25 mg, 38%).

Workup

  1. customEvaporation and purification by HPLC

Sources & evidence

ORD record
ord-b647e9d53b9047c68eaa580deec57e19
Source dataset
uspto-grants-2010_02
Patent number
US07659245B2

Reaction notes

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