Cyclopropanesulfonamide → Cyclopropanesulfonic acid [17-(7-methoxy-6-methyl-2-phenyl-quinazolin-4-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl]-amide
Reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:19][CH:20]3[CH2:37][CH:36]4[N:22]([C:23](=[O:43])[N:24]([CH3:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH:29]=[CH:30][CH:31]5[C:33]([C:39](O)=[O:40])([NH:34][C:35]4=[O:38])[CH2:32]5)[CH2:21]3)=[N:8][C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:10]2)=[CH:5][C:4]=1[CH3:44].[CH:45]1([S:48]([NH2:51])(=[O:50])=[O:49])[CH2:47][CH2:46]1>>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:19][CH:20]3[CH2:37][CH:36]4[N:22]([C:23](=[O:43])[N:24]([CH3:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH:29]=[CH:30][CH:31]5[C:33]([C:39]([NH:51][S:48]([CH:45]6[CH2:47][CH2:46]6)(=[O:50])=[O:49])=[O:40])([NH:34][C:35]4=[O:38])[CH2:32]5)[CH2:21]3)=[N:8][C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:10]2)=[CH:5][C:4]=1[CH3:44]Participants
3
Reactant 2
Product 1
Procedure
Reaction of the acid 120 (36 mg, 0.06 mmol) with cyclopropanesulfonic acid amide according to the procedure described in Example 53, gave the title compound (8 mg, 19%). MS (M−H)+ 703.
Sources & evidence
- ORD record
- ord-bcd14314a7ef436986e289e35f7141ee
- Source dataset
- uspto-grants-2010_02
- Patent number
- US07659245B2
Reaction notes
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