HCID 68410975, Verbindung → HCID 68410363, Verbindung

HRID 1443487Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1443487
[CH2:1]([O:3][C:4]([C:6]1([NH:11][C:12]([CH:14]2[CH2:18][CH:17]([O:19][C:20]3[C:29]4[C:24](=[C:25]([CH3:32])[C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([C:33]4[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=4)[N:21]=3)[CH2:16][CH:15]2[C:41](=[O:50])[N:42]([CH2:44][CH2:45][CH2:46][CH2:47][CH:48]=[CH2:49])[CH3:43])=[O:13])[CH2:8][CH:7]1C=C)=[O:5])[CH3:2]>CC1C=C(C)C(N2C(=[Ru](Cl)(Cl)=CC3C=CC=CC=3OC(C)C)N(C3C(C)=CC(C)=CC=3C)CC2)=C(C)C=1>[CH2:1]([O:3][C:4]([C:6]12[CH2:8][CH:7]1[CH:49]=[CH:48][CH2:47][CH2:46][CH2:45][CH2:44][N:42]([CH3:43])[C:41](=[O:50])[CH:15]1[CH:14]([CH2:18][CH:17]([O:19][C:20]3[C:29]4[C:24](=[C:25]([CH3:32])[C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([C:33]4[CH:34]=[CH:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=4)[N:21]=3)[CH2:16]1)[C:12](=[O:13])[NH:11]2)=[O:5])[CH3:2]

Komponenten

3

Edukt 1

HCID 68410975HCID 68410975, Verbindung

Produkt 1

HCID 68410363HCID 68410363, VerbindungAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 11763533(1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)rutheniumKatalysator

Versuchsvorschrift

The diene 135 (585 mg, 0.854 mmol) and Hoveyda-Grubbs catalyst, IInd generation (50 mg) were dissolved in degassed and dry 1,2-dichloroethane (500 mL). The mixture was heated to reflux temperature over-night under argon atmosphere. Evaporation of the solvent and purification by column chromatography (silica gel; Heptane/EtOAc 70:30) gave the title compound (420 mg, 75%). MS (M+H)+ 658.

Aufarbeitung

  1. customin degassed
  2. temperatureThe mixture was heated
  3. temperatureto reflux temperature over-night under argon atmosphere
  4. customEvaporation of the solvent and purification by column chromatography (silica gel; Heptane/EtOAc 70:30)

Quellen und Nachweise

ORD-Eintrag
ord-3d2d63e0b99b4957afb9d3e733ac3585
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07659245B2

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