反应详情

温度

40 °C

A solution of NaOH (1.58 g, 39.6 mmol) in water (40 mL) was added to 2,4-dichloro-7-methoxy-8-methylquinazoline (139) (3.2 g, 13.05 mmol) in THF (20 mL). The resulting mixture was heated at 40° C. for 24 h. Then, the reaction mixture was cooled to room temperature, THF was evaporated and additional water (30 mL) was added. The precipitate was filtered off. Then, the pH of the filtrate was adjusted to 5 with AcOH to give a solid which was subsequently filtered off and successively washed with water and isopropylether to give the title compound (2.91 g, 99%) as a yellowish powder: m/z=225 (M+H)+.

1. temperatureThen, the reaction mixture was cooled to room temperature
2. customTHF was evaporated
3. additionadditional water (30 mL) was added
4. filtrationThe precipitate was filtered off
5. customto give a solid which
6. filtrationwas subsequently filtered off
7. washsuccessively washed with water and isopropylether