HRID1443495

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCCCCN(C)C(=O)C1CC(Oc2nc(-n3ccc(C(C)C)n3)nc3c(C)c(OC)ccc23)CC1C(=O)NC1(C(=O)OCC)CC1C=C

HCID68689547

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C12CC1C=CCCCCN(C)C(=O)C1CC(Oc3nc(-n4ccc(C(C)C)n4)nc4c(C)c(OC)ccc34)CC1C(=O)N2

HCID68688284

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：CC(C)Oc1ccccc1C=[Ru](Cl)(Cl)[P](C1CCCCC1)(C1CCCCC1)C1CCCCC1

催化剂HCID178458314

未命名化合物

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

A solution of the diene (144) (230 mg, 0.335 mmol) and Hoveyda-Grubbs 1st generation catalyst (60.8 mg, 0.101 mmol) in dried and degassed 1,2-dichloroethane (230 mL) was heated at 80° C. under nitrogen for 18 h. Then, the solvent was evaporated and the residue purified by silica gel chromatography (ether) to give the target compound, m/z=659 (M+H)+.

WORKUP

后处理

customdegassed 1,2-dichloroethane (230 mL)
customThen, the solvent was evaporated
customthe residue purified by silica gel chromatography (ether)
customto give the target compound, m/z=659 (M+H)+

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4bd0e6bd57cc4aa3a6fe2e7ecfbdd247
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07659245B2
来源说明: uspto-grants-2010_02

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1([NH:11][C:12]([CH:14]2[CH2:18][CH:17]([O:19][C:20]3[C:29]4[C:24](=[C:25]([CH3:32])[C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([N:33]4[CH:37]=[CH:36][C:35]([CH:38]([CH3:40])[CH3:39])=[N:34]4)[N:21]=3)[CH2:16][CH:15]2[C:41](=[O:50])[N:42]([CH2:44][CH2:45][CH2:46][CH2:47][CH:48]=[CH2:49])[CH3:43])=[O:13])[CH2:8][CH:7]1C=C)=[O:5])[CH3:2]>CC(C)OC1C(C=[Ru](Cl)([P](C2CCCCC2)(C2CCCCC2)C2CCCCC2)Cl)=CC=CC=1>[CH2:1]([O:3][C:4]([C:6]12[CH2:7][CH:8]1[CH:49]=[CH:48][CH2:47][CH2:46][CH2:45][CH2:44][N:42]([CH3:43])[C:41](=[O:50])[CH:15]1[CH:14]([CH2:18][CH:17]([O:19][C:20]3[C:29]4[C:24](=[C:25]([CH3:32])[C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([N:33]4[CH:37]=[CH:36][C:35]([CH:38]([CH3:39])[CH3:40])=[N:34]4)[N:21]=3)[CH2:16]1)[C:12](=[O:13])[NH:11]2)=[O:5])[CH3:2]