1-({2-(Hex-5-enyl-methyl-carbamoyl)-4-[2-(3-isopropyl-pyrazol-1-yl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-cyclopentanecarbonyl}-amino)-2-vinyl-cyclopropane-carboxylic acid ethyl ester → HCID 68688284, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the diene (144) (230 mg, 0.335 mmol) and Hoveyda-Grubbs 1st generation catalyst (60.8 mg, 0.101 mmol) in dried and degassed 1,2-dichloroethane (230 mL) was heated at 80° C. under nitrogen for 18 h. Then, the solvent was evaporated and the residue purified by silica gel chromatography (ether) to give the target compound, m/z=659 (M+H)+.

Provenance & Evidence