反应详情

The quinazolinol (140) (530 mg, 2.36 mmol) was added in small portions to freshly prepared EtONa (740 mg of Na added in 20 mL EtOH). The resulting solution was heated to reflux and after 24 h, the reaction mixture was cooled down to room temperature and evaporated. The residue was re-dissolved in water (10 mL) and the pH of the resulting solution was adjusted to 5 with AcOH. The precipitate was collected by filtration, washed with ice-cooled water and dried to give the title compound (534 mg, 96.6%) as a white solid, m/z=235 (M+H)+.

1. temperatureThe resulting solution was heated
2. temperatureto reflux and after 24 h
3. customevaporated
4. dissolutionThe residue was re-dissolved in water (10 mL)
5. filtrationThe precipitate was collected by filtration
6. washwashed with ice-
7. temperaturecooled water
8. customdried