Water → 2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(3-fluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-cyclopentanecarboxylic acid

Participants

Reaction Steps

Compound 155 (0.896 g, 1.41 mmol) was dissolved in a mixture of DCM (30 mL), TFA (10 mL), a few drops of TES and a drop of H2O. The reaction was stirred for 30 minutes followed by removal of solvent by evaporation. The crude residue was partitioned between CHCl3 and saturated NaHCO3 (aq). The organic phase was dried (Na2SO4) and evaporated which gave the compound (0.81 g, 99%) as a white solid.

Provenance & Evidence