HRID1443503

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

结构：C=CC1CC1(NC(=O)C1CC(Oc2nc(-c3cccc(F)c3)nc3c(C)c(OC)ccc23)CC1C(=O)OC(C)(C)C)C(=O)OCC

HCID68412461

未命名化合物

PRODUCTS

生成物

结构：C=CC1CC1(NC(=O)C1CC(Oc2nc(-c3cccc(F)c3)nc3c(C)c(OC)ccc23)CC1C(=O)O)C(=O)OCC

HCID68686580

未命名化合物

收率 99.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

Compound 155 (0.896 g, 1.41 mmol) was dissolved in a mixture of DCM (30 mL), TFA (10 mL), a few drops of TES and a drop of H2O. The reaction was stirred for 30 minutes followed by removal of solvent by evaporation. The crude residue was partitioned between CHCl3 and saturated NaHCO3 (aq). The organic phase was dried (Na2SO4) and evaporated which gave the compound (0.81 g, 99%) as a white solid.

WORKUP

后处理

customfollowed by removal of solvent by evaporation
customThe crude residue was partitioned between CHCl3 and saturated NaHCO3 (aq)
dry with materialThe organic phase was dried (Na2SO4)
customevaporated which

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-320d2010d5314c698cce43f0085a742f
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07659245B2
来源说明: uspto-grants-2010_02

反应 SMILES

C([O:5][C:6]([CH:8]1[CH2:12][CH:11]([O:13][C:14]2[C:23]3[C:18](=[C:19]([CH3:26])[C:20]([O:24][CH3:25])=[CH:21][CH:22]=3)[N:17]=[C:16]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=3)[N:15]=2)[CH2:10][CH:9]1[C:34](=[O:46])[NH:35][C:36]1([C:41]([O:43][CH2:44][CH3:45])=[O:42])[CH2:38][CH:37]1[CH:39]=[CH2:40])=[O:7])(C)(C)C.O>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH2:44]([O:43][C:41]([C:36]1([NH:35][C:34]([CH:9]2[CH2:10][CH:11]([O:13][C:14]3[C:23]4[C:18](=[C:19]([CH3:26])[C:20]([O:24][CH3:25])=[CH:21][CH:22]=4)[N:17]=[C:16]([C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=4)[N:15]=3)[CH2:12][CH:8]2[C:6]([OH:7])=[O:5])=[O:46])[CH2:38][CH:37]1[CH:39]=[CH2:40])=[O:42])[CH3:45]