HRID1443510

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@H](O)C[C@H]1C(=O)OC(C)(C)C)C(=O)OCC

HCID59165438

未命名化合物

结构：COc1ccc2c(O)nc(-c3cc(F)cc(F)c3)nc2c1C

HCID178487740

未命名化合物

PRODUCTS

生成物

结构：C=CC1CC1(NC(=O)C1CC(Oc2nc(-c3cc(F)cc(F)c3)nc3c(C)c(OC)ccc23)CC1C(=O)OC(C)(C)C)C(=O)OCC

HCID68409531

未命名化合物

PROCEDURE

实验过程

The alcohol 15 and the quinazolinol 128 was reacted according to same procedure described in example 155 which gave the title compound as a white solid slightly contaminated by triphenyl phosphine oxide (1.245 g, >100%), LRMS (M+H) 652.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e389c77ccedd497abe015726fccf3a49
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07659245B2
来源说明: uspto-grants-2010_02

反应 SMILES

[C:1]([O:5][C:6]([C@@H:8]1[CH2:12][C@@H:11]([OH:13])[CH2:10][C@H:9]1[C:14](=[O:26])[NH:15][C@:16]1([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:18][C@H:17]1[CH:19]=[CH2:20])=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:27][C:28]1[CH:29]=[C:30]([C:35]2[N:44]=[C:43](O)[C:42]3[C:37](=[C:38]([CH3:48])[C:39]([O:46][CH3:47])=[CH:40][CH:41]=3)[N:36]=2)[CH:31]=[C:32]([F:34])[CH:33]=1>>[C:1]([O:5][C:6]([CH:8]1[CH2:12][CH:11]([O:13][C:43]2[C:42]3[C:37](=[C:38]([CH3:48])[C:39]([O:46][CH3:47])=[CH:40][CH:41]=3)[N:36]=[C:35]([C:30]3[CH:31]=[C:32]([F:34])[CH:33]=[C:28]([F:27])[CH:29]=3)[N:44]=2)[CH2:10][CH:9]1[C:14](=[O:26])[NH:15][C:16]1([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:18][CH:17]1[CH:19]=[CH2:20])=[O:7])([CH3:4])([CH3:2])[CH3:3]