(1R,2R,4S)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl) 4-hydroxy-cyclopentanecarboxylic acid tert-butyl ester → 2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(3,5-difluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-cyclopentanecarboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	(1R,2R,4S)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl) 4-hydroxy-cyclopentanecarboxylic acid tert-butyl ester	HCID 59165438	—
Reactant	HCID 178487740	HCID 178487740	—
Product	2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(3,5-difluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-cyclopentanecarboxylic acid tert-butyl ester	HCID 68409531	—

Reaction Steps

The alcohol 15 and the quinazolinol 128 was reacted according to same procedure described in example 155 which gave the title compound as a white solid slightly contaminated by triphenyl phosphine oxide (1.245 g, >100%), LRMS (M+H) 652.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07659245B2
Source dataset	uspto-grants-2010_02
ORD ID	ord-e389c77ccedd497abe015726fccf3a49
Source note	uspto-grants-2010_02