HRID1443511

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CC1CC1(NC(=O)C1CC(Oc2nc(-c3cc(F)cc(F)c3)nc3c(C)c(OC)ccc23)CC1C(=O)O)C(=O)OCC

HCID68410387

未命名化合物

HCID71413963

N-Methylhex-5-en-1-amine--hydrogen chloride (1/1)

C7H16ClN

PRODUCTS

生成物

结构：C=CCCCCN(C)C(=O)C1CC(Oc2nc(-c3cc(F)cc(F)c3)nc3c(C)c(OC)ccc23)CC1C(=O)NC1(C(=O)OCC)CC1C=C

HCID68413079

未命名化合物

收率 81%

PROCEDURE

实验过程

The acid 167 was reacted with hex-5-enyl-methyl-amine hydrochloride as according to the same procedure described in example 157, which gave the title compound (0.838 g, 81%), LRMS (M+H) 691.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-08cb3c2ae77a402986b6eaa5fa49a6fb
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07659245B2
来源说明: uspto-grants-2010_02

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1([NH:11][C:12]([CH:14]2[CH2:18][CH:17]([O:19][C:20]3[C:29]4[C:24](=[C:25]([CH3:32])[C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([C:33]4[CH:38]=[C:37]([F:39])[CH:36]=[C:35]([F:40])[CH:34]=4)[N:21]=3)[CH2:16][CH:15]2[C:41](O)=[O:42])=[O:13])[CH2:8][CH:7]1[CH:9]=[CH2:10])=[O:5])[CH3:2].Cl.[CH2:45]([NH:51][CH3:52])[CH2:46][CH2:47][CH2:48][CH:49]=[CH2:50]>>[CH2:1]([O:3][C:4]([C:6]1([NH:11][C:12]([CH:14]2[CH2:18][CH:17]([O:19][C:20]3[C:29]4[C:24](=[C:25]([CH3:32])[C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([C:33]4[CH:34]=[C:35]([F:40])[CH:36]=[C:37]([F:39])[CH:38]=4)[N:21]=3)[CH2:16][CH:15]2[C:41](=[O:42])[N:51]([CH2:45][CH2:46][CH2:47][CH2:48][CH:49]=[CH2:50])[CH3:52])=[O:13])[CH2:8][CH:7]1[CH:9]=[CH2:10])=[O:5])[CH3:2]