HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(3,5-difluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-cyclopentanecarboxylic acid → 1-{[4-[2-(3,5-Difluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-2-(hex-5-enyl-methyl-carbamoyl)-cyclopentanecarbonyl]-amino}-2-vinyl-cyclopropane-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(3,5-difluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-cyclopentanecarboxylic acid | HCID 68410387 | — |
| Reactant | N-Methylhex-5-en-1-amine hydrochloride | HCID 71413963 | — |
| Product | 1-{[4-[2-(3,5-Difluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-2-(hex-5-enyl-methyl-carbamoyl)-cyclopentanecarbonyl]-amino}-2-vinyl-cyclopropane-carboxylic acid ethyl ester | HCID 68413079 | 81% |
Reaction Steps
The acid 167 was reacted with hex-5-enyl-methyl-amine hydrochloride as according to the same procedure described in example 157, which gave the title compound (0.838 g, 81%), LRMS (M+H) 691.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07659245B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-08cb3c2ae77a402986b6eaa5fa49a6fb |
| Source note | uspto-grants-2010_02 |