Hydrochloric Acid → 1-Methylpiperidine-2-carboxylic acid

HRID 1443639Notes

Reaction equation

HRID 1443639 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[CH3:12])=[O:5])C.[OH-].[Na+].Cl>CO.O>[CH3:12][N:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH:6]1[C:4]([OH:5])=[O:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 566742Ethyl 1-methylpiperidine-2-carboxylate

Product 1

HCID 4159391-Methylpiperidine-2-carboxylic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.

Workup

  1. customevaporated to dryness
  2. customevaporated four times with toluene

Sources & evidence

ORD record
ord-e8a0cbe07a1f4296b63f9c32d27ef491
Source dataset
uspto-grants-2010_02
Patent number
US07662786B2

Reaction notes

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