反应详情

温度

40 °C

Add solution of sodium hydroxide (1.60 g, 40.0 mmol) in water (30 mL) to a solution of 7-(4-phenyloxazol-2-yl)heptanoic acid methyl ester (5.75 g, 20.0 mmol) in methanol (40 mL) at room temperature and heat the mixture at 40° C. for 2 hours. Adjust the pH of the mixture to 2 with 1 N HCl and extract with ethyl acetate (600 mL). Wash the organic extract with water (3×150 mL), dry over sodium sulfate and remove the solvent under reduced pressure. Triturate the residue with hexanes/ethyl acetate and collect the solids by filtration to provide 7-(4-phenyloxazol-2-yl)heptanoic acid (5.01 g, 91%): APCI mass spectrum m/z 272 [C16H19NO3−H]−.

1. extractionextract with ethyl acetate (600 mL)
2. washWash the
3. extractionorganic extract with water (3×150 mL)
4. dry with materialdry over sodium sulfate
5. customremove the solvent under reduced pressure
6. customTriturate the residue with hexanes/ethyl acetate
7. customcollect the solids
8. filtrationby filtration