Boron tribromide → HCID 136206536, compound

HRID 1443750Notes

Reaction equation

HRID 1443750 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[N:9]=[C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19]C)[O:11][CH:12]=1.B(Br)(Br)Br>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:21])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[N:9]=[C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[O:11][CH:12]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 59167756HCID 59167756, compound

Product 1

HCID 136206536HCID 136206536, compoundYield 48.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using a method similar to that described in Example 165, 5-[2-(2-methoxy-phenyl)-oxazol-4-yl]-pentanoic acid methyl ester (1.65 g, 5.7 mmol) with boron tribromide (1.0 M in CH2Cl2, 17.2 m/L) in CH2Cl2 gives 5-[2-(2-hydroxy-phenyl)-oxazol-4-yl]-pentanoic acid methyl ester (0.76 g, 48%). MS (ES): (M+1)+ 276.1, 277.2 m/z.

Sources & evidence

ORD record
ord-b28970827d654e2189f5f28aa437cada
Source dataset
uspto-grants-2010_02
Patent number
US07662771B2

Reaction notes

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