HCID 59168061, compound → HCID 59168059, compound

HRID 1443807Notes

Reaction equation

HRID 1443807 reaction equation
C(OC([NH:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1/[CH:15]=[CH:16]/[C:17]([O:19][CH3:20])=[O:18])=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1/[CH:15]=[CH:16]/[C:17]([O:19][CH3:20])=[O:18]

Participants

3

Reactant 1

HCID 59168061HCID 59168061, compound

Product 1

HCID 59168059HCID 59168059, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

900 mg (3.23 mmol) of the Boc-protected aminopyridine from Example 7A are dissolved in 3 ml of trifluoroacetic acid at 0° C. The reaction mixture is then stirred at room temperature for 1 h, the mixture is introduced into ice-cold sodium bicarbonate solution and stirred for 30 min, and the resulting precipitate is filtered off, washed with water and dried. 242 mg (42% of theory) of the title compound are obtained.

Workup

  1. additionthe mixture is introduced into ice-cold sodium bicarbonate solution
  2. stirringstirred for 30 min
  3. filtrationthe resulting precipitate is filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-ddc9e86b88264b14a306ccbe0b5fdec3
Source dataset
uspto-grants-2010_02
Patent number
US07662822B2

Reaction notes

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