1-(4-Fluorophenyl)piperazine → HCID 59168053, compound

HRID 1443815Notes

Reaction equation

HRID 1443815 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:4]=1[N:10]=[C:11]=[N:12][C:13]1[CH:18]=[CH:17][N:16]=[CH:15][C:14]=1/[CH:19]=[CH:20]/[C:21]([O:23][CH3:24])=[O:22].[F:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[CH:28][CH:27]=1>>[F:25][C:26]1[CH:27]=[CH:28][C:29]([N:32]2[CH2:37][CH2:36][N:35]([C:11]3[N:10]([C:4]4[CH:5]=[C:6]([CH3:9])[CH:7]=[CH:8][C:3]=4[O:2][CH3:1])[CH:19]([CH2:20][C:21]([O:23][CH3:24])=[O:22])[C:14]4[CH:15]=[N:16][CH:17]=[CH:18][C:13]=4[N:12]=3)[CH2:34][CH2:33]2)=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 86620421HCID 86620421, compound

Product 1

HCID 59168053HCID 59168053, compound

Procedure

Starting from 91 mg (0.28 mmol) of the carbodiimide from Example 16A and 76 mg (0.42 mmol) of 4-fluorophenylpiperazine, general procedure [C] and purification by preparative HPLC result in 14 mg (9% of theory) of product.

Workup

  1. customresult in 14 mg (9% of theory) of product

Sources & evidence

ORD record
ord-53a08a9957364f3e89746b3094395fa3
Source dataset
uspto-grants-2010_02
Patent number
US07662822B2

Reaction notes

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