Tetrahydrofuran → HCID 87617563, compound

HRID 1443878Notes

Reaction equation

HRID 1443878 reaction equation
C([Li])#[C:2][CH3:3].[C:5]([N:13]1[CH2:18][CH2:17][N:16]([C:19](=[O:37])[C:20]([C:22]2[C:30]3[C:25](=[C:26]([C:31]4[CH:36]=NC=CN=4)[CH:27]=[CH:28][N:29]=3)[NH:24][CH:23]=2)=[O:21])[C@H:15]([CH3:38])[CH2:14]1)(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[O:39]1CCCC1>>[C:5]([N:13]1[CH2:18][CH2:17][N:16]([C:19](=[O:37])[C:20]([C:22]2[C:30]3[C:25](=[C:26]([C:31]([CH2:36][C:2]#[CH:3])=[O:39])[CH:27]=[CH:28][N:29]=3)[NH:24][CH:23]=2)=[O:21])[C@H:15]([CH3:38])[CH2:14]1)(=[O:12])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 5280236HCID 5280236, compoundHCID 178506788HCID 178506788, compound

Product 1

HCID 87617563HCID 87617563, compound

Procedure

Propynyllithium (21 mg) was added to a solution of Example 52 (41 mg) in tetrahydrofuran (5 ml) at −78° C. The reaction was quenched with methanol at −25° C. in 2 hours. After solvents were removed under vacuum, the residue was carried to the further reactions without any purification.

Workup

  1. customThe reaction was quenched with methanol at −25° C. in 2 hours
  2. customAfter solvents were removed under vacuum
  3. customthe residue was carried to the further reactions without any purification

Sources & evidence

ORD record
ord-da15b0701d2e414493589a41bca37333
Source dataset
uspto-grants-2010_02
Patent number
US07662823B2

Reaction notes

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