Sulfuric Acid → HCID 13464813, compound

HRID 1443927Notes

Reaction equation

HRID 1443927 reaction equation
[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.N[N:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12]1.S(=O)(=O)(O)O>O>[CH:17]1[CH:16]=[CH:15][C:14]2[CH2:13][CH2:12][N:11]3[C:19]=2[C:18]=1[C:1]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]=13

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 10403CyclooctanoneHCID 27609322,3-dihydro-1H-indol-1-amine

Product 1

HCID 13464813HCID 13464813, compoundYield 30.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Following the procedure of Example 1, Step 1, cyclooctanone (6.9 mL, 52 mmol), 1-aminoindoline (7.0 g, 52 mmol) and concentrated sulfuric acid (10 mL) in water (90 mL) provided 4,5,7,8,9,10,11,12-octahydrocycloocta[b]pyrrolo[3,2,1-hi]indole (3.6 g). MS (ES) m/z 226.2.

Sources & evidence

ORD record
ord-233689e7d7db444993ebfa1bed81a00f
Source dataset
uspto-grants-2010_02
Patent number
US07662831B2

Reaction notes

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