Pyrrolidine → 2,3-Dichloro-N-[3-methoxy-5-(1-pyrrolinyl)-2-pyrazinyl]benzenesulphonamide
Reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[C:7]1[N:8]=[C:9]([O:33][CH3:34])[C:10]([N:13](COCC[Si](C)(C)C)[S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:18]=2[Cl:24])(=[O:16])=[O:15])=[N:11][CH:12]=1>>[Cl:24][C:18]1[C:19]([Cl:23])=[CH:20][CH:21]=[CH:22][C:17]=1[S:14]([NH:13][C:10]1[C:9]([O:33][CH3:34])=[N:8][C:7]([C:2]2[CH2:3][CH2:4][CH2:5][N:1]=2)=[CH:12][N:11]=1)(=[O:16])=[O:15]Participants
3
Procedure
Prepared by the method of Example 55 using pyrrolidine (0.4 g) and N-(5-bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide (0.3 g). Yield 0.045 g.
Sources & evidence
- ORD record
- ord-1b6fad2d44554c1fbbabcf85144d9437
- Source dataset
- uspto-grants-2010_02
- Patent number
- US07662825B2
Reaction notes
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