Lithium Hydroxide → [5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid

HRID 1443998Notes

Reaction equation

HRID 1443998 reaction equation
C[O:2][C:3](=[O:26])[CH2:4][S:5][C:6]1[CH:11]=[N:10][C:9]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:17]=2[Cl:23])(=[O:15])=[O:14])=[C:8]([O:24][CH3:25])[N:7]=1.[OH-].[Li+]>CO.O>[Cl:23][C:17]1[C:18]([Cl:22])=[CH:19][CH:20]=[CH:21][C:16]=1[S:13]([NH:12][C:9]1[N:10]=[CH:11][C:6]([S:5][CH2:4][C:3]([OH:26])=[O:2])=[N:7][C:8]=1[O:24][CH3:25])(=[O:15])=[O:14]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58597364[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid methyl ester

Product 1

HCID 59168222[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid methyl ester (Example 82) (0.1 g) and lithium hydroxide (0.04 g) in methanol (5 mL) and water (1 mL) was stirred at room temperature. After 2 h, the mixture was evaporated and saturated aqueous citric acid (5 mL) added. The white solid was collected, washed with water and dried. Yield 0.07 g.

Workup

  1. customthe mixture was evaporated
  2. additionsaturated aqueous citric acid (5 mL) added
  3. customThe white solid was collected
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-906e0b1595c0450b828a2ddb0d1a53a6
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

Loading…