HCID 10238792, compound → HCID 59168126, compound

HRID 1444015Notes

Reaction equation

HRID 1444015 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[C:18]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][OH:28])[CH:22]=2)=[N:17][C:16]([Cl:29])=[CH:15][N:14]=1)(=[O:11])=[O:10]>O1CCCC1.ClCCl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[C:18]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]=[O:28])[CH:22]=2)=[N:17][C:16]([Cl:29])=[CH:15][N:14]=1)(=[O:11])=[O:10]

Participants

5

Reactant 1

HCID 10238792HCID 10238792, compound

Product 1

HCID 59168126HCID 59168126, compound

Reagents, catalysts & solvents 3

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

2,3-Dichloro-N-[5-chloro-3-(3-hydroxymethylphenylmethoxy)-2-pyrazinyl]benzenesulphonamide (Example 106) (0.6 g) and manganese dioxide (1.0 g) in tetrahydrofuran (5 mL) was stirred at room temperature for 16 h. The mixture was diluted with dichloromethane and filtered through celite. The solution was evaporated to dryness and the product crystallised from diethyl ether (0.4 g). Used directly.

Workup

  1. filtrationfiltered through celite
  2. customThe solution was evaporated to dryness
  3. customthe product crystallised from diethyl ether (0.4 g)

Sources & evidence

ORD record
ord-a42b02b72133428080fbde3f2a7c4a2e
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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