Methanol → HCID 59168136, compound

HRID 1444021Notes

Reaction equation

HRID 1444021 reaction equation
Br[C:2]1[C:3]([NH2:10])=[N:4][C:5]([CH3:9])=[C:6]([Br:8])[N:7]=1.[Na].[CH3:12][OH:13]>>[Br:8][C:6]1[N:7]=[C:2]([O:13][CH3:12])[C:3]([NH2:10])=[N:4][C:5]=1[CH3:9]

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 217851463,5-Dibromo-6-methylpyrazin-2-amine

Product 1

HCID 59168136HCID 59168136, compound

Procedure

A solution of 3,5-dibromo-6-methyl-2-pyrazinamine (Example 118b) (0.9 g) was added to a solution of sodium (0.39 g) in methanol (30 mL) was heated at reflux for 18 h. After removal of solvent in vacuo, the residue was partitioned between water and dichloromethane, and the organic phase dried (MgSO4), filtered and evaporated to give the title compound as a pale yellow solid (0.58 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 18 h
  3. customAfter removal of solvent in vacuo
  4. customthe residue was partitioned between water and dichloromethane
  5. dry with materialthe organic phase dried (MgSO4)
  6. filtrationfiltered
  7. customevaporated

Sources & evidence

ORD record
ord-74658aa563b643ff8a000361e449a8c9
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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