Hydrochloric Acid → 4-[5-(1-Isopropyl-piperidin-4-yloxy)-1H-indole-2-carbonyl]-piperazine-1-carboxylic acid methyl ester

HRID 144403Notes

Reaction equation

HRID 144403 reaction equation
[CH:3]([CH3:4])([CH3:5])[N:6]1[CH2:7][CH2:8][CH:9]([O:12][c:13]2[cH:14][c:15]3[cH:16][c:17]([C:22](=[O:23])[N:24]4[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]4)[nH:18][c:19]3[cH:20][cH:21]2)[CH2:10][CH2:11]1.[Cl:30][C:31](=[O:32])[O:33][CH3:34].[ClH:1].[ClH:2]>>[CH:3]([CH3:4])([CH3:5])[N:6]1[CH2:7][CH2:8][CH:9]([O:12][c:13]2[cH:14][c:15]3[cH:16][c:17]([C:22](=[O:23])[N:24]4[CH2:25][CH2:26][N:27]([C:31](=[O:32])[O:33][CH3:34])[CH2:28][CH2:29]4)[nH:18][c:19]3[cH:20][cH:21]2)[CH2:10][CH2:11]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 6586Methyl chloroformateHCID 68565071piperazin-1-yl-[5-(1-propan-2-ylpiperidin-4-yl)oxy-1H-indol-2-yl]methanone

Product 1

HCID 685647644-[5-(1-Isopropyl-piperidin-4-yloxy)-1H-indole-2-carbonyl]-piperazine-1-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-791456569c0641d59995b825fa5ec221
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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