2-Amino-3-chloropyrazine → HCID 59168142, compound

HRID 1444034Notes

Reaction equation

HRID 1444034 reaction equation
Cl[C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][N:7]=1.[F:9][C:10]1[CH:11]=[C:12]([S:16](Cl)(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1.[CH3:20][O-:21].[Na+]>CO>[F:9][C:10]1[CH:11]=[C:12]([S:16]([NH:8][C:3]2[C:2]([O:21][CH3:20])=[N:7][CH:6]=[CH:5][N:4]=2)(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 2762242-Amino-3-chloropyrazineHCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 10942334Sodium Methoxide

Product 1

HCID 59168142HCID 59168142, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

By the method outlined in Example 1 (reaction performed at room temperature) using 3-chloro-2-pyrazinamine (1.29 g), 3-fluorobenzenesulphonyl chloride (2.13 g). The crude adduct was reacted with a solution of sodium methoxide (10 mL of a 25% solution in methanol) in methanol (20 mL) to afford the sub-titled compound (2.36 g) as a solid.

Workup

  1. customBy the method outlined in Example 1 (reaction performed at room temperature)

Sources & evidence

ORD record
ord-f1167fc1edd34e9f904a9fd9dfe24fe7
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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