2-Amino-3-chloropyrazine → HCID 59168216, compound

HRID 1444036Notes

Reaction equation

HRID 1444036 reaction equation
Cl[C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][N:7]=1.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1.[CH3:21][O-:22].[Na+]>CO>[CH3:9][O:10][C:11]1[CH:12]=[C:13]([S:17]([NH:8][C:3]2[C:2]([O:22][CH3:21])=[N:7][CH:6]=[CH:5][N:4]=2)(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 2762242-Amino-3-chloropyrazineHCID 27375043-Methoxybenzenesulfonyl chlorideHCID 10942334Sodium Methoxide

Product 1

HCID 59168216HCID 59168216, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

By the method outlined in Example 1 (reaction performed at room temperature) using 3-chloro-2-aminopyrazine (0.83 g), 3-methoxybenzenesulfonyl chloride (1.44 g). The crude adduct was reacted with a solution of sodium methoxide (10 mL of a 25% solution in methanol) in methanol (20 mL) to afford the sub-titled compound (1.41 g) as a solid.

Workup

  1. customBy the method outlined in Example 1 (reaction performed at room temperature)

Sources & evidence

ORD record
ord-4e6f1fc170524a31980cc36840a76069
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

Loading…