Sodium ethoxide → 2,3-Dichloro-N-(5-ethoxy-3-methoxy-2-pyrazinyl)benzenesulphonamide

HRID 1444048Notes

Reaction equation

HRID 1444048 reaction equation
Br[C:2]1[N:3]=[C:4]([O:28][CH3:29])[C:5]([N:8](COCC[Si](C)(C)C)[S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])(=[O:11])=[O:10])=[N:6][CH:7]=1.[O-:30][CH2:31][CH3:32].[Na+]>C(O)C>[Cl:19][C:13]1[C:14]([Cl:18])=[CH:15][CH:16]=[CH:17][C:12]=1[S:9]([NH:8][C:5]1[C:4]([O:28][CH3:29])=[N:3][C:2]([O:30][CH2:31][CH3:32])=[CH:7][N:6]=1)(=[O:10])=[O:11]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 59168156N-(5-Bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide

Product 1

HCID 591682142,3-Dichloro-N-(5-ethoxy-3-methoxy-2-pyrazinyl)benzenesulphonamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared as for Example 56 using N-(5-bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide (Example 55a) (0.3 g) and sodium ethoxide (5 mL of a 0.5M solution in ethanol). Yield 0.1 g.

Sources & evidence

ORD record
ord-8692153d95004c48965d2bee36e00ecf
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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