Acetamide, 2-mercapto-N-methyl- → 2-[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]-N-methylacetamide

Participants

Role	Name	HCID	Charge
Reactant	Acetamide, 2-mercapto-N-methyl-	HCID 4047279	—
Reactant	N-(5-Bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide	HCID 59168156	—
Product	2-[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]-N-methylacetamide	HCID 59168207	—

Reaction Steps

Prepared as for Example 101b using N-(5-bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide (Example 55a) (0.4 g) and 2-mercapto-N-methylacetamide (0.1 g). The intermediate product containing the SEM (2-[trimethylsilyl]ethoxymethyl) group was purified by silica gel chromatography eluting with ethyl acetate/iso-hexane mixtures. Deprotection as for Example 101b gave the title compound. Yield 0.05 g.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07662825B2
Source dataset	uspto-grants-2010_02
ORD ID	ord-21c492ec1e784cb49b997f99895bb06e
Source note	uspto-grants-2010_02