5-((Dimethylamino)methyl)-2-furanmethanol → HCID 10174871, compound

HRID 1444053Notes

Reaction equation

HRID 1444053 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][OH:11])=[CH:7][CH:6]=1)[CH3:3].[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[S:20]([NH:23][C:24]1[C:29](Br)=[N:28][C:27]([Br:31])=[CH:26][N:25]=1)(=[O:22])=[O:21]>>[Br:31][C:27]1[N:28]=[C:29]([O:11][CH2:10][C:8]2[O:9][C:5]([CH2:4][N:2]([CH3:1])[CH3:3])=[CH:6][CH:7]=2)[C:24]([NH:23][S:20]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]([Cl:19])[C:13]=2[Cl:12])(=[O:22])=[O:21])=[N:25][CH:26]=1

Participants

3

Reactant 2

HCID 849065-((Dimethylamino)methyl)-2-furanmethanolHCID 591682192,3-Dichloro-N-(3,5-dibromo-2-pyrazinyl)benzenesulphonamide

Product 1

HCID 10174871HCID 10174871, compound

Procedure

Prepared by the method of Example 31 using (5-dimethylaminomethyl-2-furanyl)methanol (0.2 g) and 2,3-dichloro-N-(3,5-dibromo-2-pyrazinyl)benzenesulphonamide (Example 31a) (0.2 g). Purified by silica gel chromatography eluting with methanol/dichloromethane mixtures and recrystallised from acetonitrile. Yield 0.058 g.

Workup

  1. customPurified by silica gel chromatography
  2. washeluting with methanol/dichloromethane mixtures
  3. customrecrystallised from acetonitrile

Sources & evidence

ORD record
ord-d471efd7ba9a41aea37e39681ecd510d
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

Loading…