5-[(Methylamino)methyl]-2-furanmethanol → 2,3-Dichloro-N-[3-(5-methylaminomethyl-2-furanylmethoxy)-2-pyrazinyl]benzenesulphonamide

HRID 1444059Notes

Reaction equation

HRID 1444059 reaction equation
[CH3:1][NH:2][CH2:3][C:4]1[O:8][C:7]([CH2:9][OH:10])=[CH:6][CH:5]=1.[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[S:19]([NH:22][C:23]1[C:28](Cl)=[N:27][CH:26]=[CH:25][N:24]=1)(=[O:21])=[O:20]>>[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[S:19]([NH:22][C:23]1[C:28]([O:10][CH2:9][C:7]2[O:8][C:4]([CH2:3][NH:2][CH3:1])=[CH:5][CH:6]=2)=[N:27][CH:26]=[CH:25][N:24]=1)(=[O:20])=[O:21]

Participants

3

Reactant 2

HCID 146717475-[(Methylamino)methyl]-2-furanmethanolHCID 591681672,3-Dichloro-N-(3-chloro-2-pyrazinyl)benzenesulphonamide

Product 1

HCID 591681122,3-Dichloro-N-[3-(5-methylaminomethyl-2-furanylmethoxy)-2-pyrazinyl]benzenesulphonamide

Procedure

Prepared by the method of Example 28 using (5-methylaminomethyl-2-furanyl)methanol (0.2 g) and 2,3-dichloro-N-(3-chloro-2-pyrazinyl)benzenesulphonamide (Example 28) (0.4 g). Purified by silica gel chromatography eluting with methanol/dichloromethane mixtures. Yield 0.12 g.

Workup

  1. customPurified by silica gel chromatography
  2. washeluting with methanol/dichloromethane mixtures

Sources & evidence

ORD record
ord-80c3591449d748149af6acb2f226633a
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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