N,N-Diethyl-2-hydroxyacetamide → 2-[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinyloxy]-N,N-diethyl-acetamide

HRID 1444080Notes

Reaction equation

HRID 1444080 reaction equation
Br[C:2]1[N:3]=[C:4]([O:28][CH3:29])[C:5]([N:8](COCC[Si](C)(C)C)[S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])(=[O:11])=[O:10])=[N:6][CH:7]=1.[CH2:30]([N:32]([CH2:37][CH3:38])[C:33](=[O:36])[CH2:34][OH:35])[CH3:31]>>[Cl:19][C:13]1[C:14]([Cl:18])=[CH:15][CH:16]=[CH:17][C:12]=1[S:9]([NH:8][C:5]1[N:6]=[CH:7][C:2]([O:35][CH2:34][C:33]([N:32]([CH2:37][CH3:38])[CH2:30][CH3:31])=[O:36])=[N:3][C:4]=1[O:28][CH3:29])(=[O:10])=[O:11]

Participants

3

Reactant 2

HCID 4137580N,N-Diethyl-2-hydroxyacetamideHCID 59168156N-(5-Bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide

Product 1

HCID 591681822-[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinyloxy]-N,N-diethyl-acetamide

Procedure

Prepared as for Example 115b using N-(5-bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide (Example 55a) (0.35 g) and N,N-diethyl-2-hydroxyacetamide (0.13 g). Yield 0.2 g

Workup

  1. customPrepared as for Example 115b

Sources & evidence

ORD record
ord-75223415f55d4deabca37174cf3452b3
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

Loading…