Hydrochloric Acid → HCID 67020462, compound

HRID 1444097Notes

Reaction equation

HRID 1444097 reaction equation
[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17]CC)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:20]>[OH-].[Na+]>[ClH:20].[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18997131HCID 18997131, compound

Product 1

HCID 67020462HCID 67020462, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A suspension of 1-(2-phenylethyl)-4-carbetoxypiperidine (12.2 g, 0.047 mol) obtained as described in J. Med. Chem. 1996 (39), 749-756, in 1N NaOH (100 ml) was heated under reflux for 4 h. After cooling to room temperature, the solution was made acid with 6N HCl to pH 2, concentrated by evaporation at reduced pressure, and the solid thus obtained was filtered and dried in a stove under vacuum to give the desired product (12.1 g).

Workup

  1. customobtained
  2. temperatureunder reflux for 4 h
  3. concentrationconcentrated by evaporation at reduced pressure
  4. customthe solid thus obtained
  5. filtrationwas filtered
  6. customdried in a stove under vacuum

Sources & evidence

ORD record
ord-74077a545b0d4b89a7b912a4c041a658
Source dataset
uspto-grants-2010_02
Patent number
US07662836B2

Reaction notes

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