反应详情

A suspension of 1-(2-phenylethyl)-4-carbetoxypiperidine (12.2 g, 0.047 mol) obtained as described in J. Med. Chem. 1996 (39), 749-756, in 1N NaOH (100 ml) was heated under reflux for 4 h. After cooling to room temperature, the solution was made acid with 6N HCl to pH 2, concentrated by evaporation at reduced pressure, and the solid thus obtained was filtered and dried in a stove under vacuum to give the desired product (12.1 g).

1. customobtained
2. temperatureunder reflux for 4 h
3. concentrationconcentrated by evaporation at reduced pressure
4. customthe solid thus obtained
5. filtrationwas filtered
6. customdried in a stove under vacuum