HRID1444156

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(OC)cc1)NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1

HCID131727885

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(OC)cc1)NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)O

HCID131727886

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Boc-D-Tyr(Me)-L-Ile-L-Pro-OBzl (595 mg, 1.0 mmol) was dissolved in methanol (10 mL), Pd—C (200 mg) was added, and this mixture was stirred under hydrogen atmosphere for 3 hours. Pd—C was filtered off, and methanol was removed by evaporation to obtain the desired product as a foam. Yield: 380 mg (0.8 mmol, 80%).

WORKUP

后处理

filtrationPd—C was filtered off
custommethanol was removed by evaporation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ff1eaa7180b44662bb4dae00a2f411a7
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07662778B2
来源说明: uspto-grants-2010_02

反应 SMILES

[NH:1]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[C@@H:2]([C:12]([NH:14][C@H:15]([C:20]([N:22]1[CH2:36][CH2:35][CH2:34][C@H:23]1[C:24]([O:26]CC1C=CC=CC=1)=[O:25])=[O:21])[C@H:16]([CH2:18][CH3:19])[CH3:17])=[O:13])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][CH:5]=1>CO.[Pd]>[NH:1]([C:37]([O:39][C:40]([CH3:42])([CH3:41])[CH3:43])=[O:38])[C@@H:2]([C:12]([NH:14][C@H:15]([C:20]([N:22]1[CH2:36][CH2:35][CH2:34][C@H:23]1[C:24]([OH:26])=[O:25])=[O:21])[C@H:16]([CH2:18][CH3:19])[CH3:17])=[O:13])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][CH:5]=1