反应详情

温度

60 °C

A 2 M aqueous solution (35 ml) of potassium hydroxide was added to ethyl 2-bromoimidazo[5,1-b] thiazole-7-carboxylate (1.32 g, 4.80 mmol), and the mixture was stirred at 60° C. for one hr. After the completion of the reaction, the reaction solution was poured into 4 M hydrochloric acid (20 ml) under ice cooling to precipitate a solid. The resultant solid was washed with water, and a mixed solvent composed of ethanol and toluene was added thereto. The solvent was removed by distillation under the reduced pressure, and the residue was then dried to give 2-bromoimidazo[5,1-b]thiazole-7-carboxylic acid (1.08 g, 91%) as a white solid.

1. customAfter the completion of the reaction
2. customto precipitate a solid
3. washThe resultant solid was washed with water
4. additionwas added
5. customThe solvent was removed by distillation under the reduced pressure
6. customthe residue was then dried