HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → (3-([5-(phenyl)-furan-2-carbonyl]-amino)-phenyl)-acetic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | (3-[(5-Bromo-furan-2-carbonyl)-amino]-phenyl)-acetic Acid Methyl Ester | HCID 59654700 | — |
| Product | (3-([5-(phenyl)-furan-2-carbonyl]-amino)-phenyl)-acetic Acid Methyl Ester | HCID 59654656 | — |
Reaction Steps
Methyl ester (16) (500 mg, 1.48 mmol) was coupled to phenylboronic acid (150 mg, 1.23 mmol) using Method E. The crude compound was purified by column chromatography, eluting with a stepped gradient of 20-25% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662839B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-f9442a8a47344e77a3a4ab7da48ccf27 |
| Source note | uspto-grants-2010_02 |