Phenylboronic Acid → HCID 59654853, compound

HRID 1444258Notes

Reaction equation

HRID 1444258 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13]([C:15]2[N:16]=[C:17](Cl)[S:18][CH:19]=2)=[O:14])[CH:7]=1)[CH3:2].[C:22]1(B(O)O)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13]([C:15]2[N:16]=[C:17]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[S:18][CH:19]=2)=[O:14])[CH:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 59654790HCID 59654790, compound

Product 1

HCID 59654853HCID 59654853, compound

Procedure

{3-[(2-Chloro-thiazole-4-carbonyl)-amino]-phenyl}-acetic acid ethyl ester (114 mg, 0.35 mmol) was coupled to phenylboronic acid using Method E, except that the reaction mixture was heated for 140 min. The crude residue was purified by column chromatography using 33% EtOAc in heptane to give the title compound.

Workup

  1. temperaturewas heated for 140 min
  2. customThe crude residue was purified by column chromatography

Sources & evidence

ORD record
ord-537ec4940c404a549bb2f80d09bf0087
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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