Phenylboronic Acid → HCID 68497053, compound

HRID 1444320Notes

Reaction equation

HRID 1444320 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([C:16]2[N:17]=[C:18](Cl)[S:19][CH:20]=2)=[O:15])[CH:8]=1)[CH3:2].[C:23]1(B(O)O)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:22])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([C:16]2[N:17]=[C:18]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[S:19][CH:20]=2)=[O:15])[CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 68494747HCID 68494747, compound

Product 1

HCID 68497053HCID 68497053, compound

Procedure

The chloro thiazole (114) (80 mg, 0.24 mmol) was coupled to phenylboronic acid (32 mg, 0.26 mmol) using Method E, except that the reaction mixture was heated for a total of 4 h. The crude residue was purified by column chromatography eluting with 25% EtOAc in heptane to give the title compound.

Workup

  1. temperatureexcept that the reaction mixture was heated for a total of 4 h
  2. customThe crude residue was purified by column chromatography
  3. washeluting with 25% EtOAc in heptane

Sources & evidence

ORD record
ord-0dd291f74ca4457fa1500f670ae34934
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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