反应详情

The chloro thiazole (114) (80 mg, 0.24 mmol) was coupled to phenylboronic acid (32 mg, 0.26 mmol) using Method E, except that the reaction mixture was heated for a total of 4 h. The crude residue was purified by column chromatography eluting with 25% EtOAc in heptane to give the title compound.

1. temperatureexcept that the reaction mixture was heated for a total of 4 h
2. customThe crude residue was purified by column chromatography
3. washeluting with 25% EtOAc in heptane