3-Aminobiphenyl → HCID 59654672, compound

HRID 1444324Notes

Reaction equation

HRID 1444324 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=1)[C:10]([OH:12])=O)=[O:5])[CH3:2].[C:16]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=1>>[CH2:1]([O:3][C:4](=[O:5])[CH2:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:9]([C:10](=[O:12])[NH:22][C:18]2[CH:17]=[C:16]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:21]=[CH:20][CH:19]=2)[CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 167173-AminobiphenylHCID 59654692HCID 59654692, compound

Product 1

HCID 59654672HCID 59654672, compound

Procedure

3-Ethoxycarbonylmethyl-benzoic acid (126 mg, 0.61 mmol) was coupled to biphenyl-3-ylamine (105 mg, 0.62 mmol) using Method C. The residue was purified by column chromatography eluting with 100% DCM to give the title compound.

Workup

  1. customThe residue was purified by column chromatography
  2. washeluting with 100% DCM

Sources & evidence

ORD record
ord-1ae919d94bae49119afbebc60093ce5b
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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