3-Aminocinnamic acid ethyl ester → Ethyl 3-[3-[[[6-(3,5-dichlorophenyl)-2-pyridinyl]carbonyl]amino]phenyl]-2-propenoate

HRID 1444344Notes

Reaction equation

HRID 1444344 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:14]=[C:13]([C:15]([OH:17])=O)[CH:12]=[CH:11][CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:18]([O:20][C:21](=[O:31])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH2:30])[CH:25]=1)[CH3:19]>>[CH2:18]([O:20][C:21](=[O:31])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH:30][C:15]([C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([C:4]3[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:14]=2)=[O:17])[CH:25]=1)[CH3:19]

Participants

3

Reactant 2

HCID 978253-Aminocinnamic acid ethyl esterHCID 24730153HCID 24730153, compound

Product 1

HCID 68499249Ethyl 3-[3-[[[6-(3,5-dichlorophenyl)-2-pyridinyl]carbonyl]amino]phenyl]-2-propenoate

Procedure

Carboxylic acid (131) (50 mg, 0.19 mmol) was coupled to aniline (60) (40 mg, 0.21 mmol) using Method D. The residue was triturated with TBME (3 ml) to give the title compound.

Workup

  1. customThe residue was triturated with TBME (3 ml)

Sources & evidence

ORD record
ord-23ae165dfeaa4d40b89b5dfebd02e76e
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

Loading…