反应详情

Carboxylic acid (76) (53 mg, 0.26 mmol) was coupled to aniline (124) (50 mg, 0.26 mmol) using Method C. During this reaction, hydrolysis occurred. The acid was re-dissolved in EtOAc (2 ml) and the organic layer was washed with 1M HCl (2×1 ml), dried (Na2SO4), filtered and the solvent removed in vacuo. The solid was recrystallised from a hot 10% EtOH in H2O mixture to give the title compound.

1. customDuring this reaction, hydrolysis
2. washthe organic layer was washed with 1M HCl (2×1 ml)
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. customthe solvent removed in vacuo
6. customThe solid was recrystallised from a hot 10% EtOH in H2O mixture