Water → 2-(2-Fluoro-3-methoxyphenyl)acetonitrile

HRID 1444412Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1444412
[F:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Cl.[C-:12]#[N:13].[Na+].O>CS(C)=O>[F:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][C:12]#[N:13]

Komponenten

5

Edukt 3

HCID 962WaterHCID 8929Sodium CyanideHCID 538708331-(Chloromethyl)-2-fluoro-3-methoxybenzene

Produkt 1

HCID 230744722-(2-Fluoro-3-methoxyphenyl)acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

24.89 g (142.56 mmol) of 2-fluoro-3-methoxybenzyl chloride is stirred in 200 ml of DMSO with 8.38 g (171.07 mmol) of sodium cyanide for three hours at 90° C. The reaction mixture is poured into water and extracted four times with methyl tert-butyl ether. The combined organic phases are washed with brine, dried, the desiccant is suctioned off, and the solvent is spun off. First, only a portion of the residue (21.43 g) is incorporated in crude form into the next stage.

Aufarbeitung

  1. extractionextracted four times with methyl tert-butyl ether
  2. washThe combined organic phases are washed with brine
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dcf7d9be35b54f8e869409ad30d1cc07
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07662821B2

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