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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1444563Generated: October 30, 2026

Hydrochloric Acid → HCID 68716464, compound

https://huagongshe.com/reaction/1444563

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantSodium HydroxideHCID 14798—
ReactantHCID 68717561HCID 68717561—
SolventEthanolHCID 702—
SolventWaterHCID 962—
ProductHCID 68716464HCID 6871646495.5%

Reaction Steps

A solution of 2-benzyloxycarbonylamino-2-(2-ethylbutyl)malonic acid diethyl ester (0.520 g) in ethanol (5 mL) was treated with sodium hydroxide (2.91 mL, 1 N) and then stirred at room temperature for 8 h. The reaction mixture was diluted with water and acidified with HCl and the product was then extracted with ethyl acetate to give 2-benzyloxycarbonylamino-2-(2-ethylbutyl)malonic acid monoethyl ester (0.461 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07662849B2
Source datasetuspto-grants-2010_02
ORD IDord-fd967a31ecc44454ae5e3b9b1a81c9e6
Source noteuspto-grants-2010_02