Hydrochloric Acid → HCID 68716464, compound

HRID 1444563Notes

Reaction equation

HRID 1444563 reaction equation
[CH2:1]([O:3][C:4](=[O:28])[C:5]([NH:17][C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])([CH2:11][CH:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[C:6]([O:8]CC)=[O:7])[CH3:2].[OH-].[Na+].Cl>C(O)C.O>[CH2:1]([O:3][C:4](=[O:28])[C:5]([NH:17][C:18]([O:20][CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:19])([CH2:11][CH:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[C:6]([OH:8])=[O:7])[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68717561HCID 68717561, compound

Product 1

HCID 68716464HCID 68716464, compoundYield 95.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 2-benzyloxycarbonylamino-2-(2-ethylbutyl)malonic acid diethyl ester (0.520 g) in ethanol (5 mL) was treated with sodium hydroxide (2.91 mL, 1 N) and then stirred at room temperature for 8 h. The reaction mixture was diluted with water and acidified with HCl and the product was then extracted with ethyl acetate to give 2-benzyloxycarbonylamino-2-(2-ethylbutyl)malonic acid monoethyl ester (0.461 g).

Workup

  1. extractionthe product was then extracted with ethyl acetate

Sources & evidence

ORD record
ord-fd967a31ecc44454ae5e3b9b1a81c9e6
Source dataset
uspto-grants-2010_02
Patent number
US07662849B2

Reaction notes

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